Search Result

Pathways Recommended:	Cell Cycle/DNA Damage Stem Cell/Wnt

Results for "

cell cycle at G2/M phase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) Aldehyde Dehydrogenase (ALDH) (2) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (4) Apoptosis (104) ATM/ATR (1) Aurora Kinase (1) Autophagy (4) Bacterial (1) Bcl-2 Family (7) c-Kit (1) c-Met/HGFR (3) Calcium Channel (1) Casein Kinase (1) Caspase (8) CDK (8) Cholinesterase (ChE) (1) Cytochrome P450 (1) DNA/RNA Synthesis (5) EGFR (6) Endogenous Metabolite (6) ERK (1) FAK (1) Ferroptosis (1) FGFR (1) FLT3 (2) Fluorescent Dye (1) Fungal (1) HDAC (13) Histone Acetyltransferase (1) Histone Demethylase (1) Histone Methyltransferase (1) HSP (2) HSV (1) Isotope-Labeled Compounds (4) JNK (1) MDM-2/p53 (2) Microtubule/Tubulin (34) Mitochondrial Metabolism (1) MMP (1) Mps1 (1) mTOR (1) Na+/K+ ATPase (1) NEDD8-activating Enzyme (1) NF-κB (2) PARP (8) Phosphatase (3) PI3K (5) Pim (1) Polo-like Kinase (PLK) (1) PROTACs (1) Proteasome (1) Raf (3) Ras (1) Reactive Oxygen Species (6) ROS Kinase (1) Src (1) STAT (1) TGF-beta/Smad (1) TGF-β Receptor (1) Topoisomerase (9) Tyrosinase (1) VEGFR (3)
By Research Areas:	Cancer (135) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (1)

By Targets:

Akt (4)

Aldehyde Dehydrogenase (ALDH) (2)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (4)

Apoptosis (104)

ATM/ATR (1)

Aurora Kinase (1)

Autophagy (4)

Bacterial (1)

Bcl-2 Family (7)

c-Kit (1)

c-Met/HGFR (3)

Calcium Channel (1)

Casein Kinase (1)

Caspase (8)

CDK (8)

Cholinesterase (ChE) (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (5)

EGFR (6)

Endogenous Metabolite (6)

ERK (1)

FAK (1)

Ferroptosis (1)

FGFR (1)

FLT3 (2)

Fluorescent Dye (1)

Fungal (1)

HDAC (13)

Histone Acetyltransferase (1)

Histone Demethylase (1)

Histone Methyltransferase (1)

HSP (2)

HSV (1)

Isotope-Labeled Compounds (4)

JNK (1)

MDM-2/p53 (2)

Microtubule/Tubulin (34)

Mitochondrial Metabolism (1)

MMP (1)

Mps1 (1)

mTOR (1)

Na+/K+ ATPase (1)

NEDD8-activating Enzyme (1)

NF-κB (2)

PARP (8)

Phosphatase (3)

PI3K (5)

Pim (1)

Polo-like Kinase (PLK) (1)

PROTACs (1)

Proteasome (1)

Raf (3)

Ras (1)

Reactive Oxygen Species (6)

ROS Kinase (1)

Src (1)

STAT (1)

TGF-beta/Smad (1)

TGF-β Receptor (1)

Topoisomerase (9)

Tyrosinase (1)

VEGFR (3)

By Research Areas:

Cancer (135)

Cardiovascular Disease (2)

Infection (3)

Inflammation/Immunology (2)

Metabolic Disease (2)

Neurological Disease (1)

147

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156183

Antiproliferative agent-37

Others Cancer

Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle .
HY-N10394

Metachromins X

Others Cancer

Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

Antiproliferative agent-37	Others	Cancer
Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle .

Metachromins X	Others	Cancer
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-N10670

Bursehernin Methylpluviatolide	Apoptosis	Cancer
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity .

HY-162108

Antitumor agent-128	Apoptosis	Cancer
Antitumor agent-128 (compound 1a) is an antitumor agent that elicits cell cycle arrest in both the G2/M and S phases, triggering apoptosis in A549 cells .

HY-163444

Apoptosis inducer 15	Apoptosis	Cancer
Apoptosis inducer 15 (Compound 3) induces cell apoptosis and cell cycle arrest at G2/M phase. Apoptosis inducer 15 is cytotoxicitic without causing DNA fragmentation .

HY-N10798

Kusunokinin (-)-Kusunokinin	Apoptosis	Cancer
Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis .

HY-122496

Malvidin chloride Syringidin	Apoptosis	Cancer
Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G₂/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer .

HY-147848

Tubulin polymerization-IN-27	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-27 (compound 5j) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis .

HY-147824

Tubulin polymerization-IN-22	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-22 is a tubulin polymerization inhibitor with an IC₅₀ of 8.1 μM. Tubulin polymerization-IN-22 arrests cell cycle at G2/M phase and induces apoptosis .

HY-10222

Ixabepilone 3 Publications Verification BMS-247550; Aza-epothilone B	Microtubule/Tubulin Apoptosis Bacterial	Cancer
Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.

HY-146189

Topoisomerase II inhibitor 9	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC₅₀ of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC₅₀ of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells .

HY-N2374

Eupatorin	Apoptosis	Cancer
Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-100761

SS28	Microtubule/Tubulin Apoptosis	Cancer
SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin .

HY-146818

Tubulin polymerization-IN-12	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC₅₀=0.75 μM). Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells .

HY-162291

Lck-IN-3	Src Apoptosis	Cancer
Lck-IN-3 (compound 7m) is an LCK inhibitor targeting acute lymphoblastic leukemia (ALL) that inhibits LCK phosphorylation. Lck-IN-3 can induce cell cycle arrest in the G2/M phase, leading to apoptosis in ALL cells .

HY-N6722

Swainsonine Tridolgosir
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .

HY-152099

Antiproliferative agent-19	Apoptosis	Cancer
Antiproliferative agent-19 (compound 4a) is an anti-cancer agent that exerts anti-proliferative effects on lung cancer cells by inducing apoptosis. antiproliferative agent-19 also induces cell cycle arrest in the G2/M phase .

HY-155314

Tubulin polymerization-IN-50	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-50 (compound 7n) is a inhibitor of tubulin polymerization, with the IC₅₀ of 5.05 μM in SK-Mel-28 cells. Tubulin polymerization-IN-50 induces the **cell cycle** arrest in the G2/M phase .

HY-N0421

Cinobufagin 3 Publications Verification Cinobufagine	Apoptosis	Neurological Disease Cancer
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models .

HY-N1428

Citric acid 3 Publications Verification	Apoptosis Endogenous Metabolite Antibiotic	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-149530

EGFR-IN-86	EGFR Apoptosis	Cancer
EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC₅₀: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase .

HY-N1428A

Citric acid monohydrate 2 Publications Verification
Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .

HY-162276

Anticancer agent 188	Reactive Oxygen Species DNA/RNA Synthesis	Cancer
Anticancer agent 188 (compound D43) inhibits DNA synthesis in TNBC cells, leading to **cell cycle** arrest at the G2/M phase. Anticancer agent 188 has anti-cancer viability by inducing ROS-mediated apoptosis and DNA damage .

HY-161358

FAK-IN-20	FAK Apoptosis	Cancer
FAK-IN-20 (Compound 7b) is an inhibitor of FAK with an IC₅₀ value of 0.27 nM. FAK-IN-20 exhibits anticancer activity. It can arrest the cell cycle in the G2/M phase and induce cell apoptosis (apoptosis) by generating ROS .

HY-156266

Rhizochalinin Rhiz	Others	Cancer
Rhizochalinin (Rhiz) is a cytotoxic sphingolipid. Rhizochalinin (Rhiz) counteracts glioblastoma cell proliferation by inducing apoptosis, G2/M-phase cell cycle arrest, and inhibition of autophagy. Rhizochalinin (Rhiz) can be used for human glioblastoma research .

HY-143266

Topoisomerase I inhibitor 3	Topoisomerase Apoptosis	Cancer
Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase .

HY-146188

Topoisomerase II inhibitor 8	Topoisomerase	Cancer
Topoisomerase II inhibitor 8 (compound 22) is a potent topoisomerase II inhibitor, with an IC₅₀ of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase .

HY-144340

Antitumor agent-43	DNA/RNA Synthesis Apoptosis	Cancer
Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC₅₀of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase .

HY-144754

VEGFR-2-IN-13	VEGFR Apoptosis	Cancer
VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor with an IC₅₀ of 3.4 nM. VEGFR-2-IN-13 disrupts the HepG2 cell cycle by arresting the G2/M phase and induces apoptosis .

HY-147895

PCAF-IN-2	Histone Acetyltransferase Apoptosis	Cancer
PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC₅₀ value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase .

HY-101990

IMS2186	Others	Others
IMS2186 is an antichoroidal neovascularization (CNV) reagent. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells .

HY-B2201

Citric acid trisodium 3 Publications Verification Sodium citrate; Trisodium citrate anhydrous	Apoptosis Endogenous Metabolite	Metabolic Disease
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice .

HY-145438

Antitumor agent-38	Others	Cancer
Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].

HY-146409

Antitumor agent-59	Apoptosis	Cancer
Antitumor agent-59 (Compound 13b) is a potent antitumor agent. Antitumor agent-59 effectively inhibits the proliferation and migration of HCT116 cells. Antitumor agent-59 induces HCT116 cell apoptosis and arrests the cell cycle at the G2/M phase .

HY-162311

Anticancer agent 194	Ferroptosis Autophagy Reactive Oxygen Species	Cancer
Anticancer agent 194 (compound 10p) is a ferroptosis and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS .

HY-149369

HDAC-IN-59	HDAC Apoptosis	Cancer
HDAC-IN-59 (compound 13a) is a potent histone deacetylase (HDAC) inhibitor. HDAC-IN-59 can promote the intracellular generation of ROS, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis .

HY-149370

HDAC-IN-60	HDAC Apoptosis	Cancer
HDAC-IN-60 (compound 21a) is a potent histone deacetylase (HDAC) inhibitor. HDAC-IN-60 can promote the intracellular generation of ROS, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis .

HY-146711

Tubulin inhibitor 24	Microtubule/Tubulin	Cancer
Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity .

HY-N9968

Cucurbitacin C	Akt Apoptosis	Cancer
Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling .

HY-146093

Antitumor agent-62	Apoptosis	Cancer
Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase .

HY-147771

ZLWT-37	CDK Apoptosis	Cancer
ZLWT-37 is a potent, orally active CDKs inhibitor with IC₅₀ values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells .

HY-148265

Antiproliferative agent-14	Microtubule/Tubulin	Cancer
Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC₅₀ of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle .

HY-126566

Trichostatin C	Fungal HDAC Apoptosis	Infection Cancer
Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer . Trichostatin C induces differentation of Friend leukemic cells . Trichostatin C exhibits antifungal activity .

HY-149363

Tubulin polymerization-IN-43	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis .

HY-N2374R

Eupatorin (Standard)	Apoptosis	Cancer
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-N1428S4

Citric acid-18O	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Antibiotic	Cancer
Citric acid- ¹⁸O is ¹⁸O-labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-100789

ON1231320 1 Publications Verification
ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC₅₀ of 0.31 µM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity .

HY-161268

NAE-IN-1	Apoptosis NEDD8-activating Enzyme Reactive Oxygen Species	Cancer
NAE-IN-1 (compound X-10) is a potent NAE1 inhibitor. NAE-IN-1 induces apoptosis and cell cycle arrest at the G2/M phase. NAE-IN-1 increases ROS levels and prevents cell migration. NAE-IN-1 shows anti-proliferation activity .

HY-146718

Tubulin polymerization-IN-9	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-9 is a potent tubulin inhibitor with IC₅₀ of 1.82 μM. Tubulin polymerization-IN-9 causes cell cycle arrest at G2/M phase, and induces cell apoptosis and depolarized mitochondria of K562 cells. Tubulin polymerization-IN-9 has potent anti-vascular and antitumor activities .

HY-105930

Lobaplatin 2 Publications Verification D-19466	Apoptosis Caspase Bcl-2 Family	Cancer
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122496

Malvidin chloride Syringidin	Structural Classification Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids other families Microorganisms Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G₂/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer .

HY-N2374

Eupatorin	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Source classification Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-N10394

Metachromins X	Quinones Structural Classification Classification of Application Fields Animals Terpenoids Sesquiterpenes Marine natural products Benzene Quinones Sponge Disease Research Fields Cancer	Others
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-N10670

Bursehernin Methylpluviatolide	Structural Classification Hernandia sonora Linn. other families Source classification Lignans Phenylpropanoids Plants	Apoptosis
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity .

HY-N10798

Kusunokinin (-)-Kusunokinin	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper nigrum Linn.	Apoptosis
Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis .

HY-N0421

Cinobufagin 3 Publications Verification Cinobufagine	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models .

HY-N1428

Citric acid 3 Publications Verification	Cardiovascular Disease Structural Classification Preservatives Classification of Application Fields Anti-aging Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Food Research Infection Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Inflammation/Immunology Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Antibiotic
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-B2201

Citric acid trisodium 3 Publications Verification Sodium citrate; Trisodium citrate anhydrous	Structural Classification Preservatives Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Food Research	Apoptosis Endogenous Metabolite
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice .

HY-N9968

Cucurbitacin C	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Cucumis sativus L.	Akt Apoptosis
Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling .

HY-126566

Trichostatin C	Structural Classification Natural Products Microorganisms Source classification	Fungal HDAC Apoptosis
Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer . Trichostatin C induces differentation of Friend leukemic cells . Trichostatin C exhibits antifungal activity .

HY-N2374R

Eupatorin (Standard)	Structural Classification Flavonoids Classification of Application Fields Cruciferae Source classification Phenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-B1357

Digitoxin 3 Publications Verification	Cardiovascular Disease Digitalis purpurea Linn. Structural Classification Microorganisms Classification of Application Fields Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Bcl-2 Family Caspase Apoptosis HSV Na+/K+ ATPase Calcium Channel
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

HY-N10018

Cimiside E 25-Anhydrocimigenol xyloside	Triterpenes Structural Classification Terpenoids Source classification Ranunculaceae Plants Cimicifuga racemosa (L.) Nutt.	Caspase
Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC₅₀ value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways .

HY-N2983

Cajanin	Flavonoids Classification of Application Fields Leguminosae red seaweeds Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Isoflavones	Tyrosinase
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis .

HY-N4327

Eurycomalactone	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB Apoptosis Akt Bcl-2 Family
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394) .

HY-N1039A

Manool	Natural Products Classification of Application Fields Labiatae Source classification Plants Pteris semipinnata L. Sp. Disease Research Fields Cancer Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle .

Cat. No.	Product Name	Chemical Structure

HY-N1428S4

Citric acid-18O
Citric acid- ¹⁸O is ¹⁸O-labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N1428S6

Citric acid-d4-1
Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N1428S3

Citric acid-13C3
Citric acid- ¹³C₃ is the ¹³C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].

HY-N0273S

Brassinolide-d5

Brassinolide-d₅ (Brassin lactone-d₅) is the deuterated labeled Brassinolide (HY-N0273). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-P1032S1

Angiotensin I-13C5,15N (human, mouse, rat)

Angiotensin I- ¹³C₅, ¹⁵N (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks